Table 2.

Association walking with epigenetic age acceleration using heterogeneity test, pleiotropy test, MR-PRESSO and MR-Egger

Exposures	Outcomes	Cochran’s Q (P)	MR-Egger (P)	MR-PRESSO (P)
Leisure sedentary behavior	GrimAge	0.507	0.392	0.396
	PhenoAge	0.435	0.209	0.165
	Horvath	0.179	0.982	0.163
	Hannum	0.023	0.126	0.030
Usual walking pace	GrimAge	0.272	0.861	0.364
	PhenoAge	0.091	0.019	0.057
	Horvath	0.562	0.112	0.719
	Hannum	0.307	0.899	0.305
Duration of walks	GrimAge	0.299	0.660	0.458
	PhenoAge	0.042	0.113	0.080
	Horvath	0.303	0.490	0.424
	Hannum	0.878	0.517	0.856
Frequency of walking for pleasure in last 4 weeks	GrimAge	0.052	0.031	0.072
	PhenoAge	0.587	0.738	0.702
	Horvath	0.531	0.730	0.688
	Hannum	0.624	0.276	0.710

MR-PRESSO Pleiotropy residual and outlier, RAPS Robust adjusted profile scores