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. Author manuscript; available in PMC: 2024 Jul 18.
Published in final edited form as: Toxicol Sci. 2021 Aug 3;182(2):215–228. doi: 10.1093/toxsci/kfab063

Figure 2.

Figure 2

Mapping published PBPK model structures to the model template structure. In order to implement a published model using the PBPK model template, the existing structure must be mapped onto the model template structure by setting the appropriate parameters. For each of the published models, we set unused parameters to zero, and for unused compartments we set the blood flow for that compartment to zero. Each mapping is shown here by using lighter colored arrows, boxes, and text for parameters and compartments that are “switched off” or set to zero for (a) the PFHxS model of Kim et al. (2018), (b) the PFNA model of Kim et al. (2019), (c) the PFDA model of Kim et al. (2019), and (d) the PFOA/PFOS model of Loccisano et al. (2012), which used the same model structure for both PFOA and PFOS.