Table 1.

Allometrically scaled parameters are computed as $X=X_c*A_S$, where $X_c$ is a fixed scaling coefficient defined for the parameter in question and $A_S$ is the allometrically adjusted body weight used for that parameter. Scaling coefficient values ($X_c$) and body weight (BW) are provided by the user in input files.

Parameter Name (units)	Symbol	Allometrically Adjusted Body Weight (${\mathit{A}}_{\mathit{S}}$)
Renal reabsorption transporter maximum (mg/h)	$T_{\mathrm{m}}$	BW0.75
Urinary elimination rate (1/h)	$k_{\mathrm{u}}$	BW−0.25
Transfer rate constant to urinary storage compartment (1/h)	$k_{\mathrm{u}\mathrm{s}\mathrm{t}}$	BW−0.25
Biliary excretion rate constant (1/h)	$k_{\mathrm{b}\mathrm{i}\mathrm{l}\mathrm{e}}$	BW−0.25
Transfer rate constant from fecal storage to fecal elimination (1/h)	$k_{\mathrm{f}\mathrm{s}\mathrm{t}}$	BW−0.25
Free fraction variation rate constant (1/h)	$k_{\mathrm{f}\mathrm{r}\mathrm{e}\mathrm{e}}$	BW−0.25
Cardiac output (L/h)	$Q_{\mathrm{c}\mathrm{a}\mathrm{r}\mathrm{d}\mathrm{i}\mathrm{a}\mathrm{c}}$	BW0.75