Figure 1.

Temporary expression of S100B in oligodendrocytes and astrocytes and its correlation with other common cell lineage markers. (A) In the astrocytic lineage, SOX9 is considered a pan-astrocyte lineage marker and can also be found in RGCs. Similarly, ALDH1L1 is expressed throughout astrocytic development but is more abundant during differentiation into astrocytes. GFAP is present in late RGCs and reactive astrocytes. S100B expression gradually increases in astrocytes and remains sustained into adulthood. (B) In the oligodendrocyte lineage, OLIG2 is a pan-oligodendrocyte lineage cell that maintains its expression in OPCs but is slightly downregulated in mature oligodendrocytes. SOX 10 is a transcription factor present from the OPC stage onward. S100B expression occurs slightly earlier than MYRF and is gradually downregulated in ASPA+ mature oligodendrocytes. Ols: oligodendrocytes, OPCs: oligodendrocyte progenitor cells, RGCs: radial glial cells. ASPA: Aspartoacylase, Myelin Regulatory Factor: MYRF.