Figure 3.

Visium dataset studying myocardial tissue architecture following ischemic injury. (a) Schematic figure describing the different physiological zones studied: the ischaemic zone (IZ), border zone (BZ), the unaffected left ventricular myocardium (remote zone, RZ), and control samples. (b) Comparing entire tissue samples, using Weisfeiler–Lehman Graph Kernels, to show the overall similarity in spatial organization across two conditions (RZ versus control and RZ versus IZ). The smaller the Wasserstein distance, the more similar the spatial organization is under the two compared conditions. (c) Cell-type-specific subgraphs comparison, using the portrait method, across condition pairs (RZ versus control and RZ versus IZ). The size of the dot is indicative of the dissimilarity score variance. The larger the dot size, the lower the score variance and the higher the score confidence is. (d, e) Filtration curves (RZ, IZ, and Control) for (d) Cardiomyocytes and (e) Myeloid cells. We plot a filtration curve for every sample, as well as the mean curve for every condition, which can be identified by the thicker, darker lines. Large vertical steps towards the left of the plot indicate high density, whereas large vertical steps towards the right of the plot indicate low density.