| Study | Reason for exclusion |
|---|---|
| Colombel 2013a | Not a RCT ‐ open label extension study |
| Colombel 2013b | Not a RCT ‐ pooled safety analysis |
| Feagan 2009 | Not a RCT ‐ pooled safety analysis |
| Parikh 2011a | Not a RCT ‐ pooled safety analysis |
| Parikh 2011b | Not a RCT ‐ open label extension study |
| Parikh 2013 | Not a RCT ‐ open label extension study |
| Wyant 2013 | RCT in healthy subjects |
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