Table 1.
Baseline characteristics of participants without a history of ASCVD stratified by WATCH-DM
| Low WATCH-DM (n = 2,557) |
High WATCH-DM (n = 2,332) |
P-value | |
|---|---|---|---|
| Age, years | 64.7 (10.2) | 70.7 (8.6) | <0.001 |
| Men | 1,117 (43.7) | 1,252 (53.7) | <0.001 |
| Black | 628 (24.6) | 757 (32.5) | <0.001 |
| Systolic BP, mm Hg | 132 (19) | 138 (22) | <0.001 |
| Diastolic BP, mm Hg | 72 (11) | 69 (12) | <0.001 |
| BMI, kg/m2 | 29.5 (5.4) | 32.9 (7.4) | <0.001 |
| Current smoking | 304 (11.9) | 134 (5.7) | <0.001 |
| Hypertension | 1,919 (75.0) | 2,161 (92.7) | <0.001 |
| Anti-hypertensive medication | 1,663 (65.0) | 1,955 (83.8) | <0.001 |
| Statin | 906 (35.4) | 1,190 (51.0) | <0.001 |
| Serum creatinine, mg/dL | 1.0 (0.4) | 1.4 (0.7) | <0.001 |
| HDL cholesterol, mg/dL | 49 (14) | 45 (11) | <0.001 |
| LDL cholesterol, mg/dL | 116 (38) | 106 (35) | <0.001 |
| Total cholesterol, mg/dL | 196 (45) | 185 (43) | <0.001 |
| Triglycerides, mg/dL | 161 (91) | 168 (106) | 0.01 |
| Fasting plasma glucose, mg/dL | 141 (51) | 150 (59) | <0.001 |
| QRS, ms | 87 (18) | 99 (23) | <0.001 |
| High NT-proBNP | 679 (26.6) | 1,029 (44.1) | <0.001 |
| High hs-cTn* | 331 (15.8) | 753 (39.5) | <0.001 |
| Echo-DbCM(+)* | 818 (55.7) | 1,007 (65.9) | <0.001 |
| High WATCH-DM or high NT-proBNP | 679 (26.6) | 2,332 (100) | <0.001 |
| High NT-proBNP or high hs-cTn | 900 (35.2) | 1,477 (63.3) | <0.001 |
| High NT-proBNP or echo-DbCM(+)* | 984 (67.0) | 1,207 (78.9) | <0.001 |
| Cohort | |||
| ARIC | 583 (22.8) | 622 (26.7) | <0.001 |
| CHS | 458 (17.9) | 424 (18.2) | |
| CRIC | 496 (19.4) | 906 (38.9) | |
| FHS Third Generation Cohort | 79 (3.1) | 3 (0.1) | |
| FHS Offspring Study | 109 (4.3) | 50 (2.1) | |
| MESA | 589 (23.0) | 260 (11.1) | |
| PREVEND | 243 (9.5) | 67 (2.9) | |
Data are presented as mean (standard deviation) and number (percent) for continuous and categorical variables, respectively. Comparisons across groups were performed using one-way ANOVA and chi-square test for continuous and categorical variables, respectively.
Data were available to evaluate high hs-cTn and echo-DbCM among subsets of participants (n = 4,007 and n = 2,998, respectively).
Abbreviations: ARIC, Atherosclerosis Risk in Communities Study; ASCVD, atherosclerotic cardiovascular disease; BMI, body mass index; BP, blood pressure; CHS, Cardiovascular Health Study; CRIC, Chronic Renal Insufficiency Cohort Study; CVD, cardiovascular disease; Echo-DbCM(+), echocardiogram-based diabetic cardiomyopathy; FHS, Framingham Heart Study; HDL, high-density lipoprotein; hs-cTn, high-sensitivity cardiac troponin; LDL, low-density lipoprotein; MESA, Multi-Ethnic Study of Atherosclerosis; NT-proBNP, N-terminal pro-B-type natriuretic peptide; PREVEND, Prevention of Renal and Vascular End-Stage Disease