Figure 2.

O₃-RI improves the cognition dysfunction in SD mice.

Note: (A–D) Y-maze test. (A) The spontaneous alternation rate. (B) The total arm entries. (C) The number of entries into the novel. (D) The time spent in the novel arms. (E) The recognition index in Novel object recognition test. (F–H) Open field test. (F) Average velocity. (G) Total distance. (H) Center area distance. Data are expressed as mean ± SD (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (one-way analysis of variance, followed by the Tukey's multiple comparison test). Ctrl: Control; ns: no significance; O₃-RI: ozone rectal insufflation; O₃-RI-H: high-concentration O₃-RI; O₃-RI-L: low-concentration O₃-RI; SD: sleep deprivation.