Table 3.
Pathologic parameters of colitis in experimental groups of rats. Data are presented as median (range). n = 6. Normal and control (colitis-induced) groups were treated with normal saline. *P < 0.05, **P < 0.01, and ***P < 0.001 represent significant differences compared to the control group, ###P < 0.001 versus the normal group.
| Groups | Inflammatory severity (0-3) | Inflammatory extent (0-3) | Leukocyte infiltration (0-3) | Crypt damage (0-4) | Total colitis index (0-12) |
|---|---|---|---|---|---|
| Normal | 0.0 (0-0) | 0.0 (0-0) | 0.0 (0-0) | 0.0 (0-0) | 0.0 (0-0) |
| Control | 3.0 (3-3)### | 3.0 (2-3)### | 2.0 (2-3)### | 4.0 (3-4)### | 12.0 (11-13)### |
| TIPE (125 mg/kg) | 2.0 (2-3) | 2.0 (2-3) | 2.0 (1-3) | 3.0 (3-4) | 9.0 (8-13) |
| TIPE (250 mg/kg) | 2.0 (1-3) | 1.5 (1-2)* | 1.5 (1-2) | 2.0 (2-4)* | 7.0 (5-11)* |
| TIPE (500 mg/kg) | 1.5 (0-3)* | 1.5 (1-2) | 1.5 (1-3) | 2.0 (2-3)** | 6.5 (4-11)** |
| TISE (125 mg/kg) | 1.5 (1-3)* | 1.5 (1-2)* | 1.0 (1-2)** | 1.5 (1-2)** | 5.5 (4-9)*** |
| TISE (250 mg/kg) | 1.0 (1-1)** | 0.5 (1-2)*** | 1.0 (0-1)*** | 2.0 (1-3)* | 4.5 (3-7)*** |
| TISE (500 mg/kg) | 0.5 (1-2)*** | 1.0 (1-1)*** | 1.0 (0-2)** | 1.5 (0-2)*** | 4.0 (2-7)*** |
| Prednisolone (4 mg/kg) | 0.5 (0-1)*** | 0.5 (0-1)*** | 1.0 (1-1)*** | 1.0 (1-2)*** | 3.0 (2-5)*** |
| Mesalazine (100 mg/kg) | 1.0 (0-1)** | 1.0 (1-2)*** | 1.0 (1-2)** | 1.5 (1-2)*** | 4.5 (3-6)*** |
TIPE, Tamarindus indica pulp extract; TISE, Tamarindus indica seed extract.