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[Preprint]. 2024 Jul 13:2024.07.12.603173. [Version 2] doi: 10.1101/2024.07.12.603173

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Figure 5: — (A) The HUSH and PRC1.6 complexes transcriptionally repress developmental genes and overlap at select loci. (B) Both complexes reside at endogenous promoters to safeguard against perturbation by retroviruses and retrotransposons. (C) L3MBTL2 may be recruited to HUSH loci through recognition of H3K9me3 marks previously established by the HUSH complex. (D) DNA damage may independently recruit the HUSH and PRC1.6 complexes to overlapping loci (adapted from [54]).