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. 2024 May 30;4(7):998–1013. doi: 10.1038/s43587-024-00631-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, The APA preference of ret-1 across four tissues. The boxplot’s box spans the interquartile range (IQR), with the bottom and top representing the 25th and 75th percentiles, respectively, and the mean value at the middle in this case. Whiskers extend to the smallest and largest values within 1.5 times the IQR from the quartiles. b, UMAPs showing APA site preference of ret-1 among all cell types at different ages. Age-related APA changes in the intestine cluster (circle) are highlighted with arrowheads (red for proximal; blue for distal). c, Waffle plots showing how age-related APA changes are affected by different pro-longevity mechanisms in different tissues.