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. 2024 May 30;4(7):998–1013. doi: 10.1038/s43587-024-00631-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Schematics of APA site preference toward the proximal or distal polyadenylation site (PAS). b, Heatmaps showing 55 newly identified genes with tissue-specific preference for APA sites. c, For each tissue, six examples of genes exhibiting age-related changes in APA site usage are shown. d, Percentage of genes showing an age-related shift toward the distal APA usage is decreased in different long-lived strains. e, Waffle plots showing how age-related APA changes in neurons are differently affected in the three long-lived strains. Total gene number = 67. f, APA site preference shifts of hlh-30 in neurons from day 1 to day 12 are suppressed in the rsks-1(lf) and daf-2(lf) but not the lipl-4 Tg long-lived strains. ****P < 0.0001, ***P < 0.001 and NS P > 0.05 by two-sided Wilcoxon rank-sum test with Dunn–Sidak correction. g, APA site preference shifts of daf-16 in the hypodermis from day 1 to day 12 are completely suppressed in the daf-2(lf) mutant and partially in the rsks-1(lf) mutant. NS P > 0.05; P value by two-sided Wilcoxon rank-sum test with Dunn–Sidak correction. For f and g, the box plot’s box spans the IQR, with the bottom and top representing the 25th and 75th percentiles, respectively, and the mean value at the middle in this case. Whiskers extend to the smallest and largest values within 1.5 times the IQR from the quartiles.