FIGURE 2.

NNMT Expression and Its Correlation with Gene Expression Patterns in Lung Cancer. (A) Heatmap depicting differential gene expression between high and low NNMT expression groups in lung cancer patients from the TCGA dataset. Each row represents a gene, and each column represents a patient. Color intensity reflects gene expression levels, with red indicating higher expression and blue indicating lower expression. (B) Volcano plot showing the significance versus fold-change of gene expression differences between high and low NNMT expression groups. Points represent individual genes; red points indicate significantly upregulated genes, green points indicate significantly downregulated genes, and black points represent genes with no significant difference in expression. (C–N) These analyses reveal significant correlations, indicating that NNMT expression might be closely associated with specific gene expression changes in lung cancer, suggesting its potential role in the disease’s pathology and as a marker for clinical outcomes. These genes include: CA10, GAL, CRYBA4, ARGFXP2, IGFNP1, KRT6C, GDF7, ZIC5, SLC14A2, EPGN, DSC1 and TFF1.