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. 2024 Jul 5;15:1415310. doi: 10.3389/fphar.2024.1415310

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Copyright © 2024 Wang, Zhang, You, Xu, Zhang, Li, Yang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) Differences in the expression of NNMT and autophagy between H1975 and H1975OR cells. (C) Construction of NNMT knockdown stable-turnover cells. (D) Differences in the expression of NNMT and autophagy between H1975OR, sh1 and sh2. (E–K) Statistical analysis of protein expression differences (p-value <0.05). Quantitation of these results, with comparison using an unpaired two-tailed t-test. (L) The IC50 value of H1975, H1975OR, NC, sh1, sh2. *(p < 0.05), **(p < 0.01), ***(p < 0.001), and ****(p < 0.0001).