Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 4;4(7):969–983. doi: 10.1038/s43587-024-00645-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a, UMAP visualization showing tissue niches of CTRL, IMNM and IBM muscle (spots, n = 7,462). b, Compositional analysis of tissue niches in CTRLs, IMNM and IBM (CTRLs, n = 3; IMNM, n = 2; IBM, n = 3) showing reduced proportions of myofiber-associated niche 0 in IBM compared with CTRLs and increased proportions of immune cell-associated niche 3 in IBM compared with CTRLs. Box plots show median and IQR of tissue niche proportions, with whiskers extending to the largest and smallest values within the 1.5× IQR. c, Heatmap showing spatial proximity of tissue niches. d, Heatmaps showing the correlation of spatial locations of cell types identified by snRNA-seq (upper heatmap) and scaled abundance of these cell types within tissue niches. |r|: ^*P > 0.25. e, Tissue niches shown on tissue sections of CTRL, IMNM and IBM muscle in the left column. The right columns show locations of selected cell types identified in snRNA-seq based on deconvolution of ST data (CTRL, n = 3; IMNM, n = 2; IBM, n = 3). Note, the red contours highlight areas with a low abundance of type II MNs in IBM (Fig. 1f).