Table 4.
In silico safety assessment of the antigenicity, allergenicity, and toxicity of selected peptides.
| ID | Peptide | ToxinPreda | AllergenFPb | VaxiJenc |
|---|---|---|---|---|
| Toxic/non-toxic | Allergen/non-allergen | Antigen/non-antigen | ||
| P1 | PCI-H1-004 | Non-toxic | Allergen | Antigen |
| P2 | PCI-H1-030 | Non-toxic | Non-allergen | Non-antigen |
| P3 | PCII-H1-008 | Non-toxic | Non-allergen | Antigen |
| P4 | PCI-F3-053 | Non-toxic | Allergen | Antigen |
| P5* | PCII-F3-012 | Non-toxic | Non-allergen | Non-antigen |
| P6 | PCI-IEDB-H1 | Non-toxic | Allergen | Antigen |
| P7 | LINB-IEDB-H | Non-toxic | Non-allergen | Antigen |
| P8 | PCI-F3-054 | Non-toxic | Allergen | Antigen |
| P9 | PCII-IEDB-H2 | Non-toxic | Allergen | Antigen |
| P10 | PCI-IEDB-F1 | Non-toxic | Non-allergen | Antigen |
| P11 | PCII-IEDB-F2 | Non-toxic | Non-allergen | Non-antigen |
| P12 | LINB-IEDB-F | Non-toxic | Allergen | Antigen |
*This peptide has the same sequence as P5; however, it was predicted to be present in both MHC class I and II.
aToxinPred determines whether peptides are toxic in the 10 amino acid window, with a dichotomic result indicating toxicity or nontoxicity.
bAllergenFP predicts the probability of allergenicity with a dichotomic result as probable allergen or probable no allergen.
cVaxiJen prediction of antigens and subunit vaccines with a dichotomous result as a viral antigen or nonviral antigen.