Table 2.
Characteristics of participants with and without hepatic fibrosis (LSM > 7 kPa), or with and without significant fibrosis (LSM > 8 kPa)
| Variables | LSM ≤ 7 | LSM > 7 | P-value | Variables | LSM ≤ 8 | LSM > 8 | P-value |
|---|---|---|---|---|---|---|---|
| n = 310 | n = 34 | n = 329 | n = 15 | ||||
| n (%) | n (%) | n (%) | n (%) | ||||
| Age, > 50 years | 166 (53.55%) | 24 (70.59%) | 0.058 | Age, > 50 | 180 (54.71%) | 10 (66.67%) | 0.3625 |
| Gender, male | 129 (41.61%) | 21 (61.76%) | 0.025 | Gender, male | 140 (42.55%) | 10 (66.67%) | 0.0655 |
| Diabetes* | 50 (16.13%) | 13 (38.24%) | 0.002 | Diabetes* | 57 (17.33%) | 6 (40%) | 0.0382** |
| Hypertension | 114 (36.77%) | 18 (52.94%) | 0.066 | Hypertension | 125 (37.99%) | 7 (46.67%) | 0.4994 |
| FIB-4, > 1.0¶ | 129 (41.61%) | 24 (70.59%) | 0.001 | FIB4, > 1.1¶ | 106 (32.22%) | 9 (60%) | 0.0257 |
| BMI, > 33 kg/m2¶ | 102 (32.9%) | 22 (64.71%) | < 0.001 | BMI, > 33.6 kg/m2¶ | 104 (31.61%) | 10 (66.67%) | 0.009** |
| HDL, < 42 mg/dL¶ | 77 (24.84%) | 16 (47.06%) | 0.006 | HDL, < 49 mg/dL ¶ | 152 (46.2%) | 12 (80%) | 0.0104 |
| LDL, > 96 mg/dL ¶ | 218 (70.32%) | 19 (55.88%) | 0.084 | LDL, > 94 mg/dL ¶ | 238 (72.34%) | 8 (53.33%) | 0.1418** |
| Triglycerides, > 176 mg/dL¶ | 64 (20.65%) | 12 (35.29%) | 0.051 | Triglycerides, > 177 mg/dL ¶ | 65 (19.76%) | 7 (46.67%) | 0.0204** |
¶ Cut-offs based on Youden’s index
* Defined as receipt of ≥ 1 prescription for diabetes medications in the EHR or an HbA1c ≥ 6.5%
** Fisher’s exact test