Table 3.
The final predictive model for any hepatic fibrosis (LSM > 7 kPa) or significant fibrosis (LSM > 8 kPa)
| Any fibrosis (LSM > 7 kPa) | Significant fibrosis (LSM > 8 kPa) | |||||
|---|---|---|---|---|---|---|
| Variable | OR (95% CI) | AUC (95% CI) | OR (95% CI) | AUC (95% CI) | ||
| Cut-offs based on Youden’s index | ||||||
| DM (yes vs. no) | 2.811 (1.263–6.256) | 0.7544 | 2.765 (0.905–8.45) | 0.7922 | ||
| FIB-4 (> 1 vs. ≤ 1) | 3.606 (1.623–8.011) | (0.6691–0.8396) | 4.058 (1.346–12.236) | (0.6767-9077) | ||
| BMI (> 33 vs. ≤ 33) | 3.609 (1.672–7.79) | 4.96 (1.587–15.502)* | ||||
| Cut-offs based on clinical thresholds | ||||||
| DM (yes vs. no) | 2.616 (1.198–5.711) |
0.6463 (0.5426-0.7500) |
2.247 (0.745–6.779) |
0.6979 (0.5574–0.8384) |
||
| FIB-4 (≥ 1.45 vs. < 1.45) | 1.456 (0.584–3.632) | 2.065 (0.614–6.942) | ||||
| BMI (≥ 30 vs. < 30) | 2.165 (0.925–5.068) | 4.338 (0.935–20.137) | ||||
| DM (yes vs. no) | 2.635 (1.204–5.769) | 0.6674 | 2.293 (0.751–6.997) | 0.7481 | ||
| FIB-4 (≥ 1.3 vs. < 1.3) | 2.102 (0.950–4.652) | (0.5638–0.7709) | 3.947 (1.346–11.576) | (0.6021–0.8942) | ||
| BMI (≥ 30 vs. < 30) | 2.225 (0.947–5.227) | 4.615 (0.987–21.579) | ||||
AUC, area under the receiver operating characteristic curve; CI, confidence interval; OR, odds ratio
* BMI (> 33.6 vs. ≤ 33.6 kg/m2)