Table 1.

Summary of 2017 Revised criteria for the clinical diagnosis of dementia with Lewy bodies [4]

Essential Feature •Dementia, potentially with prominent impairment in attention, executive function, and visuoperception

Core Clinical Features • Fluctuating cognition • Recurrent visual hallucinations, typically well-formed • Rapid eye movement (REM) sleep behavior disorder • Parkinsonism

Supportive Clinical Features • Antipsychotic sensitivity • Postural instability • Repeated falls • Syncope or other transient episodes of unresponsiveness • Severe autonomic dysfunction • Hypersomnia • Hyposmia • Hallucinations in non-visual modalities • Systematized delusions • Apathy, anxiety, and depression

Indicative biomarkers • Reduced basal ganglia dopamine transporter uptake (SPECT or PET imaging) • Reduced cardiac MIBG scintigraphy • Confirmation of REM sleep without atonia (polysomnography)

Supportive biomarkers • Relative preservation of mesial temporal structures (CT or MRI) • Reduced occipital activity and/or cingulate island sign (FDG-PET) • Prominent posterior slow-wave activity with periodic fluctuations in pre-alpha/theta range (EEG)

Probable DLB can be diagnosed with either: • >2 clinical features • 1 core clinical feature + >1 indicative biomarkers

Possible DLB can be diagnosed with either: • 1 core clinical feature • 0 core clinical features + >1 indicative biomarkers