TABLE 2.
Grade 3 and 4 adverse events of 4 weeks of portal infusion chemotherapy (PI4W) and gemcitabine (n = 53).
| Toxicity | PI4W Grade (CTCAE v4.0) | GEM Grade (CTCAE v4.0) | ||||||
|---|---|---|---|---|---|---|---|---|
| Grade 3 | Grade 4 | Grade 3 | Grade 4 | |||||
| N | % | N | % | N | % | N | % | |
| Hematological | ||||||||
| Leukopenia | 3 | 5.7 | 0 | 0 | 11 | 20.8 | 0 | 0 |
| Neutropenia | 4 | 7.5 | 0 | 0 | 23 | 43.4 | 4 | 7.5 |
| Anemia | 3 | 5.7 | 0 | 0 | 7 | 13.2 | 0 | 0 |
| Thrombocytopenia | 2 | 3.8 | 1 | 1.9 | 3 | 5.7 | 1 | 1.9 |
| Non‐hematological | ||||||||
| Elevated creatinine | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Elevated AST | 5 | 9.4 | 0 | 0 | 1 | 1.9 | 0 | 0 |
| Elevated ALT | 5 | 9.4 | 0 | 0 | 2 | 3.8 | 0 | 0 |
| Hyperbilirubinemia | 1 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 |
| Hyponatremia | 2 | 3.8 | 0 | 0 | 2 | 3.8 | 0 | 0 |
| Alopecia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anorexia | 2 | 3.8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Constipation | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Diarrhea | 2 | 3.8 | 0 | 0 | 1 | 1.9 | 0 | 0 |
| Fever | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nausea/Vomiting | 2 | 3.8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rash | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Stomatitis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CTCAE, Common Terminology Criteria for Adverse Events; v, version; GEM, gemcitabine; PI4W, portal vein infusion chemotherapy for 4 weeks.