FIGURE 2.

Targeting p16‐Expressing Cells Decreases Memory Precursor CD8 T cells in the Lung. At 12 DPI, lung‐infiltrating CD8 T cells were examined for surface CD127 (IL‐7Rα) expression. Both frequency of CD127+ CD8 T cells as well as mean fluorescence intensity (MFI) of CD127 among total CD8 T cells was quantified (a,b). Numbers of flu NP‐specific CD8 T cells (via influenza nucleoprotein MHC class I tetramer staining) and those expressing CD127 were also quantified (c‐f). All mice were infected using PR8. Data are presented as mean +/− standard error of the mean (SEM), and each symbol represents a single animal. Student's t‐tests were used for all comparisons with a significance level of *p < 0.05. N = 5–6 per group (3 males in GCV group and 4 males in PBS group).