Figure 1.

The effect of CDPs on Aβ₄₂ aggregation using Thioflavin T assays. The ThT fluorescence signal with only Aβ₄₂ is shown in blue. In orange is the action of CDP-1, -2, -6, and -8 in the signal of Thioflavin T, which decreased over time. (A) Provides an overview of the effect of the tested peptides against Aβ₄₂ aggregation. (B) Demonstrates the effect of different doses of CDP-1 and CDP-2 (0.5, 1, 3, 6, 13, and 28 μM) on Aβ₄₂ aggregation. The end point is shown for the relative fluorescence during a ThT assay. The Aβ₄₂ aggregation serves as the control. (C) The effect of CDP-1 against Aβ₄₂ aggregation. (D) The effect of CDP-2 against Aβ₄₂ aggregation. (E) The effect of CDP-6 against Aβ₄₂ aggregation. (F) The effect of CDP-8 against Aβ₄₂ aggregation. Data shown are the mean ± SEM from three independent measurements (n = 3). Asterisks mean that the data differ from the Aβ₄₂ control significantly at *p < 0.05, **p < 0.01, and ***p < 0.001 levels according to analyses by two-way ANOVA.