Figure 3.

sFIDA experiments to follow Aβ₄₂ aggregates elimination by CDPs. Antibody Nab228 was captured on the plate surface. After incubation of the samples, the Aβ targets were detected with IC-16 labeled with CF633. The assay surface was then imaged with the TIRFM. (A) TIRFM images of 1 nM Aβ₄₂ aggregates (1 nM) were treated with 50 nM CDPs or without CDPs (control). (B) Pixel count analysis of the TIRFM images from A. One nM Aβ₄₂ aggregates treated with 50 nM CDPs or without CDPs (control). (C) Each peptide’s signal reduction compared with the control (1 nM Aβ₄₂ aggregates). The data presented represent the mean ± SEM from three independent measurements (n = 3). Asterisks denote significant differences from the control group, where ** indicates p < 0.01 and *** indicates p < 0.001 levels of significance, as determined by analyses conducted through a two-sample t test.