Table 2. Peptide Inhibitors Targeting Aβ.
| peptidesa | prevent Aβ42 aggregation | eliminate Aβ42 aggregates | references |
|---|---|---|---|
| RYYAAFFARR | yes | - | (48) |
| pgklvya and kklvffarrrra | yes | - | (49) |
| FDYKAEFMPWDT | yes | - | (50) |
| Ac-LPFFN-NH2 | yes | - | (51) |
| KLVFF and variants | yes | - | (52,53) |
| MLRTKDLIWTLFFLGTAVS | yes | - | (54) |
| KFFEAAAKKFFE and variants | yes | - | (55) |
| TLWYK, EHWYH, HYFKY, HYYIK, and KYYEI | yes | - | (56) |
| AFRADVRAERAE and variants | yes | - | (32) |
| γ-AApeptides | yes | yes | (57) |
| lLwHsK and sHwHsK | yes | yes | (58) |
| rprtrlhthrnr, rprtrlhthrnrrprtrlhthrnr, ptlhthnrrrrrrprtrlhthrnr, and ptlhthnrrrrr | yes | yes | (36,39,59−61) |
| CDPs | yes | yes | Described in this manuscript |
a
Capital letters corresponds to l-amino acids and small letters to d-amino acids in the peptide sequences.