Fig. 4 |. GOMS related to response or lack of response to immune checkpoint inhibitors identified by meta-analysis.
The meta-analysis was performed on 12 cohorts from 8 published studies26,38–44 depicted in the x-axis labels. Species-level genome bins (SGBs) associated with objective response rates (ORRs) and identified by a meta-analysis using different differential abundance methods and adjusting for age and sex. The SGBs shown have random-effects model P values <0.05 by at least three methods. The values included inside the cells refer to unadjusted P values <0.05 obtained by two-tailed Wilcoxon tests on differences in relative abundance between responders and non-responders. Additional information is provided in Supplementary Table 7. Responders had a complete or partial response, and non-responders had stable or progressive disease. GOMS, Gut OncoMicrobiome Signatures.