Table 3.
Age, sex and subject group adjusted odds ratio (OR) and 95% confidence interval (CI) of genotypes for anti-H. pylori (Hp) antibody and anti-CagA antibody, and gastric atrophy
| Genotype | Anti-Hp antibody | Anti-CagA antibody | Gastric atrophy | |||||
| N (%) | OR (95% CI) | N (%) | OR (95% CI) | N (%) | OR (95% CI) | |||
| IL-1B C–31T | ||||||||
| TT | 39 (31.5) | 1 (Reference) | 44 (31.0) | 1 (Reference) | 11 (25.0) | 1 (Reference) | ||
| CT | 55 (44.4) | 1.01 (0.35-2.95) | 64 (45.1) | 0.52 (0.17-1.59) | 22 (50.0) | 1.39 (0.58-3.34) | ||
| CC | 30 (24.1) | 0.59 (0.25-1.39) | 34 (23.9) | 0.66 (0.16-2.76) | 11 (25.0) | 1.49 (0.52-4.27) | ||
| CT+CC | 85 (68.5) | 0.69 (0.31-1.57) | 98 (69.0) | 0.58 (0.19-1.69) | 33 (75.0) | 1.41 (0.62-3.19) | ||
| IL-2 T-330G | ||||||||
| TT | 40 (32.3) | 1 (Reference) | 45 (31.7) | 1 (Reference) | 13 (29.5) | 1 (Reference) | ||
| TG | 61 (49.2) | 1.34 (0.62-2.91) | 73 (51.4) | 2.43 (0.90-6.56) | 24 (54.5) | 1.57 (0.69-3.54) | ||
| GG | 23 (18.5) | 2.29 (0.65-8.19) | 24 (16.9) | 2.18 (0.51-9.36) | 7 (15.9) | 1.86 (0.49-6.91) | ||
| TG+GG | 84 (67.7) | 1.44 (0.69-2.99) | 97 (68.3) | 2.41 (0.97-5.99) | 31 (70.4) | 1.50 (0.69-3.29) | ||
| IL-4 C-33T | ||||||||
| CC | 39 (31.4) | 1 (Reference) | 51 (35.9) | 1 (Reference) | 16 (36.4) | 1 (Reference) | ||
| CT | 72 (58.1) | 2.33 (1.04-5.19) | 75 (52.8) | 0.62 (0.21-1.83) | 21 (47.7) | 0.71 (0.31-1.59) | ||
| TT | 13 (10.5) | 0.92 (0.29-2.92) | 16 (11.3) | 0.37 (0.09-1.53) | 7 (15.9) | 0.86 (0.26-2.87) | ||
| TT+CT | 85 (68.6) | 1.81 (0.86-3.78) | 91 (64.1) | 0.56 (0.20-1.54) | 28 (63.6) | 0.81 (0.37-1.73) | ||
| IL-8 T-251A | ||||||||
| TT | 42 (33.9) | 1 (Reference) | 48 (33.8) | 1 (Reference) | 12 (27.3) | 1 (Reference) | ||
| TA | 55 (44.3) | 1.27 (0.53-3.02) | 61 (43.0) | 1.22 (0.41-3.69) | 22 (50.0) | 1.64 (0.68-3.96) | ||
| AA | 27 (21.8) | 0.59 (0.23-1.48) | 33 (23.2) | 0.69 (0.23-2.17) | 10 (22.7) | 1.13 (0.41-3.13) | ||
| TA+AA | 82 (66.1) | 0.97 (0.46-2.06) | 94 (66.2) | 1.00 (0.39-2.57) | 32 (72.7) | 1.44 (0.65-3.19) | ||
| IL-10 T-819C | ||||||||
| CC | 47 (37.9) | 1 (Reference) | 53 (37.3) | 1 (Reference) | 13 (29.5) | 1 (Reference) | ||
| CT | 62 (50.0) | 1.38 (0.62-3.07) | 71 (50.0) | 1.67 (0.61-4.59) | 23 (52.3) | 1.75 (0.77-3.99) | ||
| TT | 15 (12.1) | 0.54 (0.18-1.61) | 18 (12.7) | 0.61 (0.17-2.18) | 8 (18.2) | 1.78 (0.58-5.48) | ||
| CT+TT | 77 (62.1) | 1.13 (0.55-2.35) | 89 (62.7) | 1.32 (0.54-3.23) | 31 (70.5) | 1.67 (0.77-3.62) | ||
| IL-13 C-1111T | ||||||||
| CC | 66 (53.3) | 1 (Reference) | 78 (54.9) | 1 (Reference) | 22 (50.0) | 1 (Reference) | ||
| CT | 52 (41.9) | 0.96 (0.46-2.00) | 58 (40.9) | 0.71 (0.28-1.78) | 20 (45.5) | 0.97 (0.46-2.06) | ||
| TT | 6 (4.8) | not calculated | 6 (4.2) | not calculated | 2 (4.5) | 2.95 (0.36-24.35) | ||
| CT+TT | 58 (46.7) | 1.09 (0.52-2.25) | 64 (45.1) | 0.81 (0.33-2.02) | 22 (50.0) | 0.99 (0.48-2.08) | ||
| TNF-A C-857T | ||||||||
| CC | 79 (63.7) | 1 (Reference) | 90 (63.4) | 1 (Reference) | 29 (65.9) | 1 (Reference) | ||
| CT | 44 (35.5) | 2.06 (0.88-4.79) | 50 (35.2) | 3.22 (0.89-11.58) | 15 (34.1) | 0.95 (0.43-2.07) | ||
| TT | 1 (0.8) | 0.34 (0.03-4.22) | 2 (1.4) | 0.42 (0.03-5.70) | 0 (0) | not calculated | ||
| CT+TT | 45 (36.3) | 1.75 (0.79-3.87) | 52 (36.6) | 2.57 (0.81-8.06) | 15 (34.1) | 0.89 (0.41-1.94) | ||
| TNF-A T-1031Ｃ | ||||||||
| TT | 82 (66.1) | 1 (Reference) | 97 (68.3) | 1 (Reference) | 29 (65.9) | 1 (Reference) | ||
| TC | 41 (33.1) | 2.82 (1.05-7.57) | 44 (31.0) | 3.22 (0.85-12.19) | 15 (34.1) | 1.17 (0.52-2.62) | ||
| CC | 1 (0.8) | 0.12 (0.01-1.25) | 1 (0.7) | 0.10 (0.01-1.16) | 0 (0) | not calculated | ||
| TC+CC | 41 (33.9) | 1.93 (0.82-4.55) | 45 (31.7) | 1.72 (0.59-4.91) | 15 (34.1) | 1.01 (0.46-2.26) | ||
Underlined ORs are statistically significant (p <0.05)