Table 1.

Community Involvement Activities in the PLATINUM Trial

Activity	Activity Description	Impact on Trial
CAP	Includes persons recovered from mpox, sexual health workers who have treated mpox patients, gay and bisexual, and other men who have sex with men, and people with HIV; contributed to study protocol, participant information sheet, consent form, patient recruitment poster and flyer, participant questionnaire, press release, and website	Increased inclusivity and appropriateness of language used in patient-facing materials
Raising awareness	Presentation of trial at conferences by community members (eg, HIV Glasgow); interview with community podcast “What the Pox?”; hosting a stall at Manchester Pride festival 2023 to provide information about the trial to festival attendees	Identification of potential avenues for raising trial awareness that are outside routine trial recruitment strategies; increased community awareness about the trial
Training	Training provided to CAP members on trial background, planned future training on scientific publications	Increased community member understanding of the trial and research in general
	Community-delivered training in stigma and HIV history to trial team as a result of steering committee recommendation	Whole trial team invited to training; attendees gained greater understanding of the stigma faced by groups at risk of mpox and appropriate language and terminology to use when engaging with those communities
Community representation in steering committee	A CAP member is a member of the trial steering committee; training in stigma and HIV history was recommended by the community representative	Community voice present in trial governance
Communication with clinics	Advice from CAP on how to recruit potential participants in clinics across the country	Patient-centered and language-appropriate recruitment posters and flyers
Community organization engagement	Support from Terrence Higgins Trust, UK Community Advisory Board, Positively UK, NAM AIDSMAP, Prepster, and HIV i-Base; HIV i-Base, Positively UK, and the British HIV Association have included the trial on their websites	Increased community and healthcare worker awareness of the trial, including diverse high-risk community groups
Trial launch	CAP reviewed the press release, provided a statement within the release, and tweeted about the trial launch alongside supporting organizations; this, together with trial team and university tweets, potentially reached >1.4 million people, and the trial was covered by community media channel PinkNews	Improving awareness for potential participants beyond those normally reached by research organization engagement

Abbreviations: CAP, Community Advisory Panel; HIV, human immunodeficiency virus.