Table 1.
Clinical and laboratory features
| Parameters | Cases | Mean (±SD) | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | ||
| Age (years) | 30 | 26 | 28 | 35 | 25 | 42 | 28.8±3.54 |
| Genotype | S/S | S/B° | S/B° | S/S | S/S | S/C | |
| PMH | Splenectomy and cholecystectomy | ACS, bilateral AVN | ACS, AVN | Acute MI, ACS, AVN hips and shoulder, auto-splenectomy | Fat embolism syndrome, reflex nephropathy | Asthma, ACS, splenectomy, | |
| Presenting symptoms | fever, headache, cough, SOB, and chest pain | VOC, Mental Nerve syndrome | VOC, rhinorrhea | VOC, fever, tachycardia | VOC | Cough, mild pain | |
| Gestation at diagnosis | 22 | 31 | 20 | 28 | 30 | 8 | 26.2±4.4 |
| Gestation at delivery | 37 | 36+5 | 37 | 39 | 37+1 | Aborted at W11 | 37.4±0.8 |
| Birth weight (kg) | 2.13 | 2.50 | 2.44 | 2.66 | 2.73 | NA | 2.43 (0.2) |
| Length of stay | 7 | 12 | Home | 9 | 5 | home | 8.25 (2.5) |
| COVID severity | Moderate | Moderate | Mild | Moderate | Mild | Mild | |
| Therapy received | Ceftriaxone, azithromycin, oseltamivir, LMWH, exchange transfusions | Simple and exchange transfusions, LMWH | Oral pain medications | Tazocin, azithromycin, oseltamivir, LMWH, exchange transfusion | Exchange transfusions, LMWH | Cefuroxime and azithromycin | |
| Red cell units used during episode | 3 | 4 | 0 | 4 | 3 | ||
| Baseline Hb | 9.2 | 9.4 | 9 | 8.9 | 9.3 | 10.3 | 9.16±0.19 |
| Hb at presentation | 7.7 | 8.1 | 8.8 | 8.2 | 7.9 | NA | 8.14 (0.4) P<0.001 |
| Baseline WBC | 16.4 | 4.4 | 7.4 | 7.9 | 6.1 | 6.7 | 8.44±4.16 |
| WBC at presentation | 10.9 | 6.1 | 5.9 | 10.5 | 17.2 | NA | 10.12 (4.1) P=0.5 |
| Baseline platelets | 478 | 123 | 145 | 451 | 258 | 420 | 291±149.13 |
| Platelets (109) at presentation | 413 | 122 | 124 | 282 | 112 | NA | 210 (49) P=0.4 |
| LDH U/l | 1184 | 648 | NA | 243 | 597 | NA | 668 (36) |
| Serum ferritin µg/l | 7173 | 1161 | NA | 2286 | 7747 | NA | 4591 (290) |
| CRP µg/l | 48 | 74 | NA | 25 | 64 | NA | 52 (18) |
| D. Dimers mg/l | NA | 3.9 | NA | 3.2 | 3.86 | NA | 3.65 (0.3) |
VOC=Vaso-occlusive crisis, ACS=Acute chest syndrome, AVN=Avascular necrosis, PMH=Past medical history, NA=Not available, WBC=White blood cell, CRP=C-reactive protein, Hb=Hemoglobin, LMWH=Low-molecular-weight heparin, SD=Standard deviation, MI=Myocardial infarction, LDH=lactate dehydrogenase, SOB=shortness of breath