Table 1. Homology-based design of putative intragenic suppressor mutations for EFR.

The list contains the residue number of EFR and the analogous oncogenic mutation in BRAF, as well as a short description of the mode of action of the oncogenic mutation. See Figure 2—figure supplement 1B for structural locations.

EFR mutation	Analogous oncogenic mutation	Mode of action	Source
L743F	BRAF L485F	Extended hydrophobic interaction network along the αC-helix	Hu et al., 2015
F761[H/M]	BRAF L505[F/H/M]	Enforcement of hydrophobic interactions in the regulatory spine	Hu et al., 2015
ΔNLLKH	BRAF ΔNVTAP	Shortening of β3-αC-helix loop, pulling ‘in’ the αC-helix	Foster et al., 2016
L873E	BRAF V600E	Upward bending of C-terminal αC-helix end	Hu et al., 2015