Table 1.
Demographics, clinical characteristics, and outcomes of 81 patients with P. aeruginosa ST1203 with blaVIM-80 and blaGES-9, by culture source*
| Characteristic | All Case-Patients, N = 81 | Eye, N = 21 | Urinary, N = 15 | Respiratory, N = 13 | Blood, N = 3 | Other clinical, N = 2† | Surveillance, N = 27 |
|---|---|---|---|---|---|---|---|
| Demographics— n/N (%) | |||||||
| Age (years) Mean (SD) |
60 (24) | 75 (14) | 70 (22) | 44 (31) | 72 (5) | 67 (10) | 49 (19) |
| Median (range) | 63 (0–102) | 76 (42–102) | 70 (21–100) | 52 (0–83) | 74 (67–76) | 67 (60–74) | 51 (12–87) |
| Patient Sex—Male | 40/80 (50) | 9/21 (43) | 5/15 (33) | 6/12 (50) | 1/3 (33) | 1/2 (50) | 18/27 (67) |
| Setting of culture collection— n (%) | |||||||
| Inpatient Acute Care Hospital | 22 (27) | 3 (14) | 8 (53) | 8 (62) | 2 (67) | 1 (50) | 0 (0) |
| Long Term Acute Care Hospital | 27 (33) | 0 (0) | 1 (6.7) | 3 (23) | 0 (0) | 0 (0) | 23 (85) |
| Skilled nursing facility | 5 (6.2) | 0 (0) | 1 (6.7) | 0 (0) | 0 (0) | 0 (0) | 4 (15) |
| Emergency Department | 6 (7.4) | 2 (9.5) | 2 (13) | 1 (7.7) | 1 (33) | 0 (0) | 0 (0) |
| Outpatient clinic | 21 (26) | 16 (76) | 3 (20) | 0 (0) | 0 (0) | 1 (50) | 0 (0) |
| Underlying medical conditions— n (%)‡ | |||||||
| Charlson Comorbidity Index (CCI)—median (range) | 1 (0–12) | 1 (0–8) | 1 (0–8) | 2 (0–12) | 4 (2–6) | 3 (3–3) | 1 (0–8) |
| No CCI underlying conditions | 18 (22) | 5 (24) | 4 (27) | 2 (15) | 0 (0) | 0 (0) | 7 (26) |
| Diabetes | 19 (23) | 8 (38) | 3 (20) | 2 (15) | 0 (0) | 1 (50) | 5 (19) |
| Chronic lung disease | 16 (20) | 6 (29) | 3 (20) | 4 (31) | 1 (33) | 0 (0) | 2 (7.4) |
| Cerebrovascular disease | 14 (17) | 2 (9.5) | 4 (27) | 3 (23) | 1 (33) | 0 (0) | 4 (15) |
| Dementia | 13 (16) | 2 (9.5) | 1 (6.7) | 0 (0) | 1 (33) | 0 (0) | 9 (33) |
| Cancer | 13(16) | 2 (9.5) | 3 (20) | 2 (15) | 2 (67) | 2 (100) | 2 (7.4) |
| Any eye disease§ | 30 (37) | 19 (90) | 3 (20) | 1 (7.7) | 1 (33) | 1 (50) | 5 (19) |
| Glaucoma | 16 (20) | 13 (62) | 1 (6.7) | 0 (0) | 1 (33) | 0 (0) | 1 (3.7) |
| Cataracts | 14 (17) | 9 (43) | 2 (13) | 1 (7.7) | 1 (33) | 0 (0) | 1 (3.7) |
| Indwelling devices in place up to 3 months prior to first culture collection— n/N (%)‖ | |||||||
| No devices | 22/73 (30) | 14/15 (93) | 6/14 (43) | 0 (0) | 0 (0) | 1 (50) | 1 (3.7) |
| Tracheostomy | 39/75 (52) | 0 (0) | 3/14 (21) | 11 (85) | 0 (0) | 0 (0) | 25/26 (96) |
| Percutaneous endoscopic gastrostomy tube | 32/73 (44) | 0/15 (0) | 3/14 (21) | 7 (54) | 1 (50) | 0 (0) | 21 (78) |
| Invasive urinary catheter | 16/73 (22) | 0/15 (0) | 5/14 (36) | 5 (38) | 1 (50) | 0 (0) | 5 (19) |
| Mechanical Ventilation | 26/73 (36) | 0/15 (0) | 2/14 (14) | 9 (69) | 0 (0) | 0 (0) | 14 (52) |
| Outcomes for case-patients with incident clinical cultures—n/N (%) | |||||||
| Provider documented infection¶ | 42/50 (84) | 21 (100) | 8/11 (73) | 9 (69) | 3 (100) | 1 (50) | -- |
| New hospitalization** | 34/49 (69) | 11/18 (61) | 10/15 (67) | 10 (77) | 1 (50) | 0/1 (0) | -- |
| New intensive care unit admission** | 10/41 (24) | 0/14 (0) | 0/8 (0) | 7/10 (70) | 2 (100) | 1/1 (100) | -- |
| Death within 30 days of culture collection | 4/39 (10) | 1/17 (5.9) | 1/10 (10) | 0/9 (0) | 2 (100) | 0/1 (0) | -- |
Denominators are included for variables with missing data
Culture sources include wound (n=1) and ear (n=1)
The most frequent underlying medical condition for each specimen category is listed; full list in Supplementary Appendix File S6
Any eye disease reported includes: glaucoma (n=16), cataracts (n=14), macular degeneration (n=3), ocular hypertension (n=2), Sjorgren’s disease (n=2), blepharitis (n=1), retinal artery/vein occlusion (n=1), vitreomacular adhesion (n=1), undifferentiated anterior corneal surface disorder (n=1), lagophalmos (n=1), recurrent corneal erosion (n=1), filimentary keratitis (n=1), corneal stromal dystrophy (n=1), and ocular cicatricial pemphigoid (n=1).
Three most common devices reported among all case-patients, not including mechanical ventilation; full list in Supplementary Appendix File S6.
Associated infection with P. aeruginosa documented in the medical record
Hospitalization and admission to the intensive care unit (ICU) defined as new hospital or ICU admission, respectively, within 3 days prior to 2 weeks after culture collection. New admission to the ICU includes patients who were already hospitalized (i.e., admission more than 3 days prior to culture collection), but were transferred to ICU during timeframe of interest