Table 4.

Interaction between tobacco exposure and total sugar intake on the risk of dental caries in adults.

	Crude model		Model 1		Model 2
	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
Cotinine and total sugar level
Cotinine ≤10 ng/mL and total sugar ≤19.5%E	Ref		Ref		Ref
Cotinine >10 ng/mL and total sugar ≤19.5%E	1.42 (1.18–1.71)	<0.001	1.56 (1.28–1.90)	<0.001	1.34 (1.09–1.65)	0.006
Cotinine ≤10 ng/mL and total sugar >19.5%E	1.39 (1.21–1.59)	<0.001	1.39 (1.19–1.63)	<0.001	1.44 (1.23–1.69)	<0.001
Cotinine >10 ng/mL and total sugar >19.5%E	2.65 (2.19–3.21)	<0.001	3.05 (2.55–3.64)	<0.001	2.76 (2.29–3.33)	<0.001
RERI	0.840 (0.276–1.404)		1.094 (0.487–1.701)		0.980 (0.413–1.547)
API	0.317 (0.147–0.487)		0.359 (0.202–0.516)		0.355 (0.192–0.517)
SI	2.037 (1.248–3.323)		2.148 (1.363–3.384)		2.250 (1.344–3.767)

OR: odds ratio; CI: confidence interval; Ref: Reference; RERI: relative excess risk of interaction; SI: the synergy index; API: attributable proportion of interaction.

Crude model: Weighted univariable logistic regression model.

Model 1: Weighted multivariable logistic regression model adjusted for age, gender, race, education, and PIR.

Model 2: Weighted multivariable logistic regression model adjusted for age, gender, race, education, PIR, drink, physical activity, hypertension, diabetes, dyslipidemia, CVD, bone loss around teeth, BMI, fiber intake, last dental visit, dental care, frequency of using dental floss.