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. 2024 Apr 17;19(3):1434–1442. doi: 10.1016/j.jds.2024.04.002

Figure 2.

Figure 2

Pg-OMVs-induced neurotoxicity in SH-SY5Y cells. (A) Bright-field morphology of undifferentiated SH-SY5Y treated with different concentrations of Pg-OMVs for 24 h. Scale bar, 100 μm. (B) MTT assay evaluation of the effect of Pg-OMVs on neuronal cell viability. For dose-dependence, Pg-OMVs were given at concentrations of 5, 10, and 20 μg/mL for 24 h. (C) Western blot analysis of cleaved PARP (cPARP) in SH-SY5Y cells upon exposure to different concentrations of Pg-OMVs for 24 h. (D) The relative quantification of cPARP expression normalized to β-actin. The bar represents the mean ± SEM of three different experiments (∗P < 0.05). (E) Bright-field morphology of differentiated SH-SY5Y cells treated with different concentrations of Pg-OMVs for 24 h. Scale bar, 100 μm. (F) Western blot analysis of Syn and GAP43 in differentiated SH-SY5Y cells upon exposure to different concentrations of Pg-OMVs for 24 h.