FIGURE 4.

Extracellular matrix secreted by connective tissue fibroblasts can influence the alignment of muscle cells. Representative examples of the results of plating muscle cells (HMC25 line labelled with GFP) on connective tissue fibroblast‐derived matrix produced by control (a) or radial dysplasia (RD) (b) patient cell lines. A box and whisker plot of order parameter values demonstrating muscle cells are significantly less aligned when seeded on RD cell line (n = 6 different patient cell lines) derived matrix compared with when grown on control patient cell line (n = 4 different cell lines) derived matrix (c). Control, blue. RD, red.