FIGURE 5.

Type III, V and VI collagen expression in connective tissue fibroblast‐derived extracellular matrix. Patient cell‐derived extracellular matrix from control patients (a–f) positively stained with type III (a, d), V (b, e) and VI (c, f) collagen in all cell‐derived matrices analysed. Radial dysplasia cell‐derived matrices (g–x) stained positively for type V (h, k, n, q, t and w) and VI collagen (l, o, r, u and x). Type III collagen was significantly downregulated or absent radial dysplasia cell‐derived matrix (g, j, m, p, s and v) when compared to the control type III collagen‐stained matrices (a, d).