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. 2024 Jun 21;10(1):veae047. doi: 10.1093/ve/veae047

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© The Author(s) 2024. Published by Oxford University Press.

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Figure 2. — Comparison of the meq oncogene in Md5 and CVI988 consensus genomes. Schematic representation of the meq isoforms found in the repeat long regions (IRL shown here) in CVI988 (blue/top panel) and Md5 (red/bottom panel) consensus genomes. The meq oncogene is comprised of the proline/glutamine (Pro/Gln)-rich domain, the basic region (BR), the leucine zipper (ZIP), and the transactivation domain (TAD) at the C-terminal region. Differences in the AA sequence of the two strains are highlighted and labeled (A = Alanine, E = Glutamic acid, I = Isoleucine, K = Lysine, P = Proline, S = Serine, T = Threonine, V = Valine). The Meq protein is 339 AA in length. The L-Meq isoform contains a 59-AA insertion in the TAD, resulting in a total length of 398 AA.