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. 2024 Jun 25;10(13):e33618. doi: 10.1016/j.heliyon.2024.e33618

Fig. 3.

Fig. 3

Assessment of changes in collagen and tumor-infiltrating lymphocyte (TIL) components within the tumor microenvironment (TME) of patients with high-grade serous ovarian carcinoma following neoadjuvant chemotherapy (NACT). a Qualitative visualization of changes in the collagen and TIL components within the TME of pre- and post-NACT H&E images. b Quantitative changes in the TIL component (TIL density, mean density of epithelial TIL clusters, mean density of stromal TIL clusters) within the TME of pre- and post-NACT H&E images. c Quantitative changes in the collagen component (mean, minimum, and maximum entropy values of collagen fiber orientation disorder) within the TME of pre- and post-NACT H&E images. TIL, tumor-infiltrating lymphocytes; TME, tumor microenvironment; NACT, neoadjuvant chemotherapy; CFOD, collagen fiber orientation disorder. P-value, Wilcoxon matched-paired signed-ranked test for paired samples.