Table 3. Recurrent Stroke Outcomes in PRoFESS and IRIS by Poststroke Categories of mRS.
| mRS score | Stroke event rate, % | Unadjusted HR (95% CI) | P value | Adjusted HR (95% CI)a | P value |
|---|---|---|---|---|---|
| PRoFESS | |||||
| 0 (n = 2834) | 7.2 | 1 [Reference] | NA | 1 [Reference] | NA |
| 1-2 (n = 12 570) | 8.7 | 1.27 (1.09-1.47) | .002 | 1.18 (1.01-1.37) | .03 |
| ≥3 (n = 4779) | 10.6 | 1.63 (1.38-1.92) | <.001 | 1.36 (1.14-1.61) | <.001 |
| IRIS | |||||
| 0 (n = 1096) | 6.4 | 1 [Reference] | NA | 1 [Reference] | NA |
| 1-2 (n = 1862) | 9.0 | 1.44 (1.09-1.90) | .011 | 1.36 (1.02-1.80) | .03 |
| ≥3 (n = 307) | 11.7 | 1.91 (1.28-2.86) | .002 | 1.79 (1.19-2.70) | .006 |
Abbreviations: IRIS, Insulin Resistance Intervention After Stroke; mRS, modified Rankin Scale; NA, not applicable; PRoFESS, Prevention Regimen For Effectively Avoiding Second Strokes.
a
Adjusted for baseline age, gender, race and ethnicity, region or country of enrollment, current smoking, atrial fibrillation, hypertension, hyperlipidemia, prior stroke, randomization group, days from qualifying stroke to enrollment, and Trial of ORG 10172 in Acute Stroke Treatment classification of the qualifying stroke. PRoFESS is also adjusted for diabetes.