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DLT in Assessable Patients
| Parameter, (n%) | Avelumab + Lorlatinib (n = 28) | Avelumab + Crizotinib (n = 12) |
|---|---|---|
| DLT | 2 (7) | 5 (42) |
| ALT increased | 2 (7) | 2 (17) |
| AST increased | 0 | 2 (17) |
| ECG QT prolonged | 0 | 1 (8) |
| Febrile neutropenia | 0 | 1 (8) |
| Immune-mediated hepatitis | 0 | 1 (8) |
| Rash | 0 | 1 (8) |
Note: Patients with more than one DLT are counted only once.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; DLT, dose-limiting toxicity; ECG, electrocardiogram.
