| Trial name or title |
The Coronis Trial. |
| Methods |
International multicentre study of caesarean section surgical techniques: a randomised fractional, factorial trial. |
| Participants |
Women undergoing their first or second caesarean section through a transverse abdominal incision. |
| Interventions |
Five comparisons using a 2 x 2 x 2 x 2 x 2 fractional factorial design:
Blunt versus sharp abdominal entry. Exteriorisation of the uterus for repair versus intra‐abdominal repair. Single versus double layer closure of the uterus. Closure versus non‐closure of the peritoneum (pelvic and parietal). Chromic catgut versus Polyglactin‐910 for uterine repair.
|
| Outcomes |
Primary outcome: death or maternal infectious morbidity (one or more of the following: antibiotic use for maternal febrile morbidity during postnatal hospital stay, antibiotic use for endometritis, wound infection or peritonitis) or further operative procedures; or blood transfusion. |
| Starting date |
Not stated in reports. |
| Contact information |
The CORONIS Trial Collaborative Group, Peter Brocklehurst: peter.brocklehurst@npeu.ox.ac.uk |
| Notes |
|
