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. 2024 Jul 8;15:1403272. doi: 10.3389/fimmu.2024.1403272

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Copyright © 2024 Ni, Cui, Yang, Ding, Zhao, Hu, Zhan, Kang, Hu, Zhao, Xu, Chen, Liu, Zhao, Zhang, Huang, Li, Yang, Zhang, Zhang, Deng, Yang, Lu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upregulated genes associated with ER in G-MDSCs may protect patients from aGvHD. (A) Genetic overlap was analyzed across three cohorts: Cohort A examined genes related to heme oxygenase-1, Cohort B focused on differentially expressed genes (DEGs) in G-MDSCs comparing day 90 (n=7) to day 28 (n=4) in patients without subsequent aGvHD, and Cohort C analyzed DEGs in G-MDSCs at day 28 in patients with (n=3) versus without (n=4) subsequent aGvHD. (B) GO terms for intersecting genes across three G-MDSC cohorts (A-B-C, A-C, A-B intersections) were identified. (C) Heatmap shows DEGs associated with the endoplasmic reticulum (ER) at day 28 between patients without subsequent aGvHD (n=4) and those with (n=3). (D) At day 42, patients with grades 0-I aGvHD showed higher percentage of interleukin-10 (IL-10) in G-MDSCs compared to those with grades II-IV aGvHD (n=16). (E, F) By day 60, patients with grades 0-I aGvHD had increased IL-10 percentages and more IL-10⁺ G-MDSCs than those with grades II-IV aGvHD (n=23).