Table 2.
Subgroup analysis of the prognostic value of TA-HEVs for OS in solid tumor.
| Subgroup analysis | No.of studies | Effect model | Pooled HR (95%CI) | Heterogeneity I2 (%) |
P | |
|---|---|---|---|---|---|---|
| OS | ||||||
| Total | 8 | Fixed | 0.75 (0.62, 0.93) | 13 | 0.33 | |
| Ethnicity | ||||||
| Asian | 5 | fixed | 0.63 (0.49, 0.82) | 0 | 0.65 | |
| Caucasian | 3 | fixed | 1.03 (0.73, 1.44) | 0 | 0.76 | |
| Sample size | ||||||
| <200 | 6 | fixed | 0.82 (0.64, 1.06) | 17 | 0.30 | |
| ≥200 | 2 | fixed | 0.65 (0.47, 0.91) | 0 | 0.36 | |
| Tumor type | ||||||
| Gastrointestinal cancer | 4 | Fixed | 0.67 (0.51, 0.88) | 0 | 0.8 | |
| Others | 4 | Fixed | 0.87 (0.64, 1.19) | 45 | 0.14 | |
| Cut-off value | ||||||
| Median | 3 | Fixed | 0.77(0.55, 1.08) | 37 | 0.30 | |
| Non-median | 5 | Fixed | 0.75(0.58,0.96) | 17 | 0.21 | |
| Source of HR | ||||||
| Reported | 4 | fixed | 0.63 (0.48, 0.81) | 0 | 0.51 | |
| K-M curves | 4 | fixed | 1.02 (0.73, 1.41) | 0 | 0.90 | |
HR, hazard ratio; CI, confidence; OS, overall survival; K-M, Kaplan-Meier.