FIG. 6.

Alignment of the predicted Nef amino acid sequences derived from patients FA and MB. The two-digit number in the left column gives the year of PBMC collection, and the last number specifies the individual clone. The Nef consensus sequences derived from NPs (Non-Con) and progressors (Pro-Con) are shown at the bottom for comparison. The Non-ex and Pro-ex sequences also contain those variations that were more frequently observed in NPs or RPs but did not alter the NP and RP consensus Nef sequences. The nine amino acid positions corresponding to those at which differences between Nef sequences derived from NPs and RPs were observed are indicated by stars above the alignment. The positions of additional N-terminal PxxP motifs in deduced FA and MB Nef sequences are shaded. Abbreviations and symbols are described in the legend to Fig. 1.