TABLE 2.
Differences between Nef sequences derived from NPs, SPs, and RPs
| Nef variationa | No. (%) of occurrences in:
|
P valueb
|
||||
|---|---|---|---|---|---|---|
| NPs (n = 41) | Progressors
|
|||||
| SPs (n = 18) | RPs (n = 32) | Total (n = 50) | NPs vs all progressors | NPs vs RPs | ||
| N-terminal PxxP | 1 (2) | 2 (11) | 8 (25) | 10 (20) | <0.03 | <0.01 |
| T15 | 21 (51) | 3 (17) | 10 (31) | 13 (26) | <0.03 | 0.14 |
| A15 | 14 (34) | 10 (56) | 16 (50) | 26 (53) | 0.13 | 0.26 |
| R39 | 0 (0) | 4 (22) | 6 (19) | 10 (20) | <0.02 | <0.02 |
| T51 | 12 (29) | 9 (50) | 21 (66) | 30 (60) | <0.01 | <0.005 |
| N51 | 28 (68) | 9 (50) | 10 (31) | 19 (38) | <0.01 | <0.005 |
| H102 | 14 (34) | 3 (13) | 5 (16) | 8 (16) | 0.08 | 0.12 |
| T157 | 3 (7) | 1 (6) | 13 (41) | 14 (28) | <0.03 | <0.005 |
| C163 | 8 (20) | 5 (25) | 16 (50) | 21 (41) | <0.04 | 0.01 |
| N169 | 1 (2) | 1 (6) | 9 (28) | 10 (20) | <0.03 | <0.005 |
| L170 | 28 (68) | 11 (61) | 9 (28) | 20 (41) | <0.02 | <0.002 |
| Q170 | 12 (29) | 7 (39) | 22 (69) | 29 (58) | 0.01 | <0.002 |
| M182 | 5 (12) | 5 (28) | 14 (44) | 19 (39) | 0.01 | <0.005 |
| E182 | 16 (39) | 4 (22) | 4 (13) | 8 (16) | <0.03 | <0.03 |
a
Positions are those indicated by shaded ovals in Fig. 2.
b
Determined by the chi-square test with the Yates correction.