Figure 3.

GATA6⁺ pericardial macrophages influence pericardial inflammation in response to myocardial tissue damage

(A) Schematic of experimental design.

(B) CD45⁺ leukocytes as a percentage of live cells (Lys^Cre sham n = 4, Lys^Cre infarct n = 9, Lys^CreGATA6^fl/fl sham n = 4, Lys^CreGATA6^fl/fln = 8) within the pericardium alone.

(C) Pie charts comparing major leukocyte compartments between Lys^Cre and Lys^CreGATA6^fl/fl mice based on surgical status of sham or infarction. Proportions are a percentage of CD45⁺ cells.

(D) CD3⁺ cells as a proportion of CD45⁺ cells.

(E) SiglecF⁺ cells as a proportion of CD45⁺ cells.

(F) F4/80⁺ cells as a percentage of CD45⁺ cells.

(G) CD19⁺ cells as a percentage of CD45⁺ cells.

(H) TCRγδ⁺ cells as a percentage of CD45⁺ cells.

(I) Ly6G⁺SiglecF⁺ cells as a percentage of CD45⁺ cells. Statistics: two-way ANOVA with Tukey’s multiple comparisons test. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.