Figure 4.

GATA6⁺ pericardial macrophages do not protect from cardiac remodeling in myocardial infarction

(A) Representative histology showing whole cross section between Lys^Cre and Lys^CreGATA6^fl/fl mice. Zoom: 1.25×, scale bar: 200 μm.

(B) Percent fibrotic area calculated via MATLAB (Lys^Cren = 8, Lys^CreGATA6^fl/fln = 10).

(C) Representative histology of the infarct zone.

(D) Percent fibrotic area of the infarct zone.

(E) Representative histology of the border zone.

(F) Percent fibrotic area of the border zone.

(G) Representative histology of the remote zone.

(H) Percent fibrotic area of the remote zone.

(I) Ejection fraction (EF).

(J) Intraventricular septal end diastole (IVSD).

(K) Left ventricular internal diameter end diastole (LVIDD).

(L) Left ventricular posterior wall end diastole (LVPWD). Zoomed in sections are 20× zoom, scale bar: 50 μm. Scale bars for zoomed in sections of (E) are applicable to zoomed in sections of (F) and (G). Statistics: Student’s t test with Welch’s correction. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.