Table 7.
To exclude the potentially confounding effects of age on the association of coronary artery disease with ApoE gene polymorphisms, multivariate logistic regression analysis stratified according to age was performed.
| Variables | Adjusted Odd Ratio (OR) (95 % CI), p Value |
|||
|---|---|---|---|---|
| ＜45 years old | ≥45 and ≤ 59 years old | ≥60 and ≤ 74 years old | ≥75 years old | |
| ε3/ε4 vs ε4/ε4 | 0.334(0.057–1.952), P = 0.223 | 0.617(0.306–1.245), P = 0.177 | 1.404(0.670–2.940), P = 0.369 | 1.043(0.100–10.899), P = 0.972 |
| ε3/ε3 vs ε4/ε4 | 0.233(0.042–1.284), P = 0.094 | 0.684(0.347–1.346), P = 0.272 | 1.413(0.684–2.917), P = 0.351 | 1.212(0.118–12.461), P = 0.872 |
| ε2/ε4 vs ε4/ε4 | 0.357(0.042–3.059), P = 0.347 | 0.404(0.152–1.073), P = 0.069 | 0.790(0.312–2.000), P = 0.619 | 0.342(0.027–4.298), P = 0.406 |
| ε2/ε3 vs ε4/ε4 | 0.096(0.014–0.658), P = 0.017* | 0.517(0.252–1.062), P = 0.072 | 1.063(0.504–2.242), P = 0.872 | 0.757(0.072–7.935), P = 0.816 |
| ε2/ε2 vs ε4/ε4 | 0.146(0.005–4.059), P = 0.256 | 1.092(0.318–3.748), P = 0.888 | 0.908(0.288–2.866), P = 0.869 | 3.021(0.130–70.197), P = 0.491 |
| ε3/ε4 vs ε3/ε3 | 1.433(0.753–2.729), P = 0.274 | 0.902(0.708–1.149), P = 0.404 | 0.994(0.825–1.197), P = 0.947 | 0.861(0.591–1.253), P = 0.434 |
| ε2/ε4 vs ε3/ε3 | 1.534(0.398–5.917), P = 0.534 | 0.590(0.287–1.214), P = 0.152 | 0.559(0.309–1.014), P = 0.055 | 0.282(0.102–0.784), P = 0.015a |
| ε2/ε3 vs ε3/ε3 | 0.414(0.158–1.083), P = 0.072 | 0.756(0.567–1.007), P = 0.056 | 0.753(0.607–0.933), P = 0.009a | 0.624(0.427–0.914), P = 0.015a |
| ε2/ε2 vs ε3/ε3 | 0.625(0.035–11.315), P = 0.751 | 1.597(0.564–4.523), P = 0.378 | 0.643(0.260–1.588), P = 0.338 | 2.493(0.296–20.977), P = 0.401 |
| ε3/ε4 vs ε2/ε2 | 2.292(0.122–43.080), P = 0.579 | 0.565(0.196–1.628), P = 0.290 | 1.546(0.618–3.871), P = 0.352 | 0.345(0.040–2.967), P = 0.333 |
| ε2/ε4 vs ε2/ε2 | 2.453(0.105–57.512), P = 0.577 | 0.369(0.105–1.295), P = 0.120 | 0.870(0.298–2.545), P = 0.800 | 0.113(0.011–1.185), P = 0.069 |
| ε2/ε3 vs ε2/ε2 | 0.661(0.033–13.164), P = 0.786 | 0.473(0.164–1.366), P = 0.166 | 1.171(0.469–2.924), P = 0.735 | 0.250(0.029–2.132), P = 0.205 |
| ε2/ε4 vs ε3/ε4 | 1.070(0.254–4.507), P = 0.926 | 0.654(0.310–1.380), P = 0.265 | 0.563(0.305–1.037), P = 0.065 | 0.328(0.113–0.948), P = 0.040a |
| ε2/ε3 vs ε3/ε4 | 0.289(0.097–0.856), P = 0.025a | 0.838(0.593–1.183), P = 0.314 | 0.757(0.584–0.982), P = 0.036a | 0.725(0.447–1.176), P = 0.193 |
| ε2/ε3 vs ε2/ε4 | 0.270(0.054–1.347), P = 0.110 | 1.281(0.599–2.740), P = 0.524 | 1.346(0.725–2.499), P = 0.347 | 2.214(0.768–6.379), P = 0.141 |
a
Indicates p < 0.05.