Table 2.

Roles of ALKBH1 in human non-cancer diseases.

Diseases type	Expression	Modification types	Modification expression in diseases	Biological functions	Molecular mechanisms	Targets	Reference
CKD	up	DNA 6mA	down	Aggravating medial vascular calcification (VC) progression and osteogenic reprogramming	Facilitating the binding of octamer-binding transcription factor 4 (Oct4) to the bone morphogenetic protein 2 (BMP2) promoter and activates BMP2 transcription	BMP2	98
Hypertension	up	DNA 6mA	down	Angiotensin II-induced vascular remodeling	Regulating hypoxia-inducible factor 1α (HIF1α)	HIF1α	100
AS	up	DNA 6mA	down	Promoting the oncogenic role of the hypoxia-response gene myocardial infarction-associated transcript (MIAT)	Facilitating HIF1α binding and activation of MIAT	HIF1α	107
AAA	down	m1A	No study	No study	No study	No study	111