Table 3.

Inhibitor of ALKBH1.

Interactions between the inhibitors and ALKBH1 [112]
Binding Site	Mechanism	Inhibitors	Residues of ALKBH1
2-OG binding site	salt bridge interaction with –COOH	LipotF, citrate,2,4-PDCA,NOG,IOX1,IOX3	Arg338
	hydrogen bonding with C O/-COOH/-OH	2,4-PDCA,NOG,rhein, fluorescein	Arg 334
	hydrogen bonding with C O/-COOH/-OH	citrate,NOG,entacapone	Asn220
	hydrogen bonding with –COOH	LipotF,2,4-PDCA,NOG,IOX1,IOX3	Asn340
	hydrogen bonding with –COOH	LipotF,2,4-PDCA,NOG,IOX3	Met 376
substrate-binding site	water-mediated bond	FB23	Arg 234
	Hydrogen bonding with pyridyl nitrogen/-OH/nitrogen or oxygen atom of heterocyclic ring	LipotF, CHTB
	π-π interactions with -C6H5	rhein, CHTB,LipotF	His 231
	hydrogen bonding with –OH	CHTB	Val 232
	π-π interactions with -C6H5	LipotF	Tyr177
	hydrogen bonding with –OH	entacapone	Tyr184
	hydrogen bonding with –OH	CDPCB	Phe 27
	Van der Waals contact with -Cl	CDPCB	Leu 228
	hydrophobic interaction with --C6H5	LipotF