FIG. 5.

Structure of ORF50 IE mRNAs and the ORFs they encode. (A) Schematic representation of the intron-exon structures of ORF50 mRNAs. Numbers indicate nucleotide positions in the KSHV genome (24). All three types of mRNA initiate at or near position 71513 and end at position 76737. Exons are presented with boxes, and introns are presented with lines. Each type of mRNA has three putative ORFs, namely, ORF50, K8, and K8.2 as indicated. ORF K8 shows three distinct forms (designated α, β, and γ) as a result of alternative splicing. (B) Amino acid sequences of three forms of KSHV ORF K8. The acidic domain and the basic-leucine zipper domain are indicated. (C) Amino acid sequence of putative ORF K8.2.