TABLE 4.
Comparison between cases with and without AMR in the whole cohort of patients.
| No AMR (n = 185) | AMR (n = 28) | p-value | ||
|---|---|---|---|---|
| Donor age, years | 45 (36–55) | 42 (30–46) | 0.07 | |
| Donor gender, n (%) (missing cases = 5) | Male | 82 (45) | 18 (67) | 0.04 |
| Female | 99 (55) | 9 (33) | ||
| Donor ethnicity, n (%) (missing cases = 8) | White | 156 (88) | 20 (74) | 0.07 |
| Ethnic minorities | 22 (12) | 7 (26) | ||
| Recipient age, years | 45 (35–55) | 43 (31–48) | 0.18 | |
| Recipient gender, n (%) | Male | 97 (52) | 9 (32) | 0.06 |
| Female | 88 (48) | 19 (68) | ||
| Recipient ethnicity, n (%) | White | 160 (87) | 20 (71) | 0.05 |
| Ethnic minorities | 25 (13) | 8 (29) | ||
| Recipient dialysis status, n (%) | Pre-emptive | 51 (28) | 2 (7) | 0.03 |
| HD or PD | 134 (72) | 26 (93) | ||
| Duration on dialysis, months | 17 (0–47) | 44 (12–104) | 0.002 | |
| Peak cRF | 97 (81–99) | 98 (95–100) | 0.15 | |
| Total DSA MFI, baseline | 9,125 (5,355–15530) | 18,700 (7,017–40007) | 0.005 | |
| Number of previous transplants, n (%) | First transplant | 123 (66) | 18 (64) | 0.83 |
| Second or more | 62 (34) | 10 (36) | ||
| High risk relation between recipient and donor, n (%) | No | 147 (80) | 17 (61) | 0.03 |
| Yes | 38 (20) | 11 (39) | ||
| HLA mismatch level, n (%) | Level 0, 1 and 2 | 37 (20) | 7 (25) | 0.61 |
| Level 3 and 4 | 148 (80) | 21 (75) | ||
| DSA to repeat mismatch, n (%) (missing cases = 6) | No | 145 (80) | 10 (38) | <0.001 |
| Yes | 36 (20) | 16 (62) | ||
Values expressed as Median (IQR), unless otherwise stated. Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; cRF, calculated reaction frequency; HLA, human leukocyte antigen; DSA MFI, Donor specific antibody-mean fluorescence index. *DSA MFI, and cRF, values are presented only for HLAi, and high-risk transplant.